Hormone Optimization

Bi-Est Cream

A cream that combines two estrogens — the more powerful estradiol and the gentler estriol — that works to improve hot flashes, skin changes, mood issues and more.

  • Reduced hot flashes and night sweats

  • Improved mood and concentration

  • Help prevent osteoporosis (low bone density)

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Starting at $50 for one month's supply

Product Information

Who it's for
Bi-Est Cream can be helpful for women experiencing symptoms of estrogen deficiency or menopause, including:
  • Hot flashes or night sweats

  • Poor sleep

  • Vaginal dryness and/or painful sex

  • Dry skin

  • Hair loss

  • Heart palpitations

  • Increase in allergies

  • Benefits
  • Eliminates hot flashes and night sweats

  • Improves mood and concentration

  • Reduces risk of osteoporosis

  • Improves skin and hair

  • Improves sleep

  • Decreases vaginal dryness

  • Improves cholesterol, especially heart protective HDL cholesterol

  • What to expect
  • Estrogen treatment benefits may be noticed in as little as 2 weeks, but it can take up to 8 weeks to feel the full effect. Your Modern Age clinician will work with you to optimize the dose for your body.

  • Downsides: 
  • Most women do not experience side effects, but some may experience weight gain, fatigue, dizziness, lightheadedness, or breast tenderness. 

  • Safety information
    For anyone with a uterus who is prescribed Bi-Est Cream, we will also prescribe Progesterone. This is to prevent increased thickness of the uterine lining. Progesterone (P4) prevents this build-up to ensure there is no increased risk for developing endometrial hyperplasia and cancer.  

    If you have a history of breast or endometrial cancer, are a BRCA1/2 carrier, have undiagnosed vaginal bleeding, coronary heart disease, blood clots or stroke, estrogen use may not be recommended. 

    The prescription you need, without the hassle

    • Diagnostic testing

      Your clinician will take your medical history and order diagnostic testing to understand your hormone levels, then create a personalized plan for you.

    • Speedy shipping

      If this product is right for you, you'll get it shipped directly to your home. Anyone with a uterus will also be prescribed progesterone.

    • Ongoing support

      Your Modern Age clinician will check in with you as you take your hormones to ensure you have optimal dosage and benefits.

    How to use

    It's best to apply the cream after showering, to allow maximum absorption.
    Apply to your inner thigh or as directed by your clinician.
    Gently rub a thin layer of the cream into your skin.
    Good to know
    Once applied, avoid swimming, showering or exercising for at least forty minutes, as this can wash away the cream and reduce efficacy.

    Common Questions

    Does estrogen treatment increase the risk of breast cancer or other cancers?
    No. Recent analyses has revealed that estrogen may in fact help prevent breast cancer, which refuted the 2002 report by Women's Health Initiative that estrogen treatment could increase the risk of this disease. Plus, the original study was assessing oral treatments that are rarely used anymore. 
    How long will I need to be on estrogen therapy?
    There is no set time to stop taking estrogen. In some cases, it's only until hormone levels are good and vaginal health is improved. In others, it might be beneficial to continue taking it on an ongoing basis to ensure your hormone levels remain properly balanced. Your clincian will work with you closely to ensure you stay on estrogen for the right amount of time for you. 
    How do I choose between Bi-Est Cream and other estrogen options, like the Estrogen Patch?
    Bi-Est Cream contains two forms of estrogen — estradiol and estriol. Estradiol is the much more potent of the two. For some women it can be beneficial to blend a gentler estrogen like estriol to reduce side effects. This combination of estrogen can be adjusted to precisely meet the needs of your body. If you have struggled with side effects when using estrogen patches or other forms of hormone therapy, Bi-Est may be a good option for you.
    Are estrogen pills an option?
    We do not offer estrogen treatment in pill form, primarily because there is suggestive evidence that taking oral estrogen is more strongly associated with heightened risk of blood clots and stroke as compared to estrogen patches or creams. Non-oral routes like this cream bypasses this risk.
    Why should I get estrogen treatment with Modern Age, when I could also get it from OBGYN or Primary Care?
    OB/GYNs are reproductive health experts, not necessarily hormonal health experts. Modern Age clinicians are specifically trained on hormonal health and the effects it has on your body as you get older. We also perform hormone diagnostic testing to guide our treatments, which allows us to offer a personalized experience with effective results. 

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