Vaginal Estradiol Cream

This estrogen treatment directly addresses vaginal dryness and irritation for women before, during, or after menopause.

  • Reduced vaginal dryness

  • Reduced irritation and pain during sex

  • Increased lubrication for sex

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$80 for one month's supply

Product Information

Who it's for
Vaginal Estradiol Cream can be beneficial for women experiencing vaginal dryness, which sometimes leads to pain or discomfort during sex. This is a common symptom of estrogen deficiency for women approaching menopause and onward. However, since most of the estrogen will stay in the vaginal tissue, this type of treatment will not help with hot flashes or osteoporosis.
  • Reduces vaginal dryness

  • Reduces irritation and pain during sex

  • Increases lubrication to aid sex 

  • Decreases vaginal infections

  • Helps prevent UTIs

  • What to expect
  • For some women, estrogen treatment benefits can be noticed in as little as 1-2 weeks, but it can take a few months to experience full benefits. 

  • It can also take some time to optimize dosage for your body — your Modern Age clinician will work with you to understand how it's working and adjust as needed.

  • Downsides:
  • Vaginal Estradiol Cream is generally well tolerated, and side effects are uncommon. In clinical studies some women experienced headaches, hives increase in vaginal discharge, and breast tenderness, but these symptoms were mild and rare.

  • The prescription you need, without the hassle

    • Diagnostic testing

      Your clinician will take your medical history and order diagnostic testing to understand your hormone levels, then create a personalized plan for you.

    • Speedy shipping

      If this this product is right for you, you'll get a custom prescription shipped directly to your home.

    • Ongoing support

      Your Modern Age clinician will check in with you as you take the hormones to ensure you have optimal dosage.

    How to use

    Use as directed by your clinician. Typically, we suggest using daily for several weeks, then decreasing to 3 times a week. It’s best to apply it at bedtime.
    Fill the applicator with the Estradiol Cream. Insert the applicator high into the vagina and press the plunger to release the medication. Afterward, clean the applicator with warm soapy water and rinse well.

    What our experts say

    For women whose primary symptoms of estrogen deficiency are vaginal dryness and irritation, vaginal estrogen cream can be a good option.

    ~ Dr. Anant Vinjamoori, MD

    Common Questions

    Does estrogen treatment increase the risk of breast cancer or other cancers?
    No. Recent analyses has revealed that estrogen may in fact help prevent breast cancer, which refuted the 2002 report by Women's Health Initiative that estrogen treatment could increase the risk of this disease.

    The original study was looking at oral treatments that are rarely used anymore. Also, vaginal estradiol products treat locally, meaning they aren't absorbed into your system like a pill. So there is no concern with this type of estrogen therapy.
    How long will I need to be on estrogen therapy?
    There is no set time to stop taking estrogen. In some cases, it's only until hormone levels are good and vaginal health is improved. In others, it might be beneficial to continue taking it on an ongoing basis to ensure your hormone levels remain properly balanced. Your clinician will work with you closely to ensure you stay on estrogen for the right amount of time for you.
    Why should I get estrogen treatment with Modern Age, when I could also get it from OBGYN or Primary Care?
    OB/GYNs are reproductive health experts, not necessarily hormonal health experts. Modern Age clinicians are specifically trained on hormonal health and the effects it has on your body as you get older. We also perform hormone diagnostic testing to guide our treatments, which allows us to offer a personalized experience with effective results. 
    What does research say about Vaginal Estradiol Cream?
    Vaginal estrogen, or Vaginal Estradiol Cream, is one of the most effective treatment options for vaginal dryness. 

    It is also shown to be safe and low-risk. As a local treatment, it’s administered precisely to the location it’s treating, so less estrogen enters the bloodstream than when taking the hormone in other ways (e.g. orally). This reduces the risk of cancers and cardiovascular issues associated with estrogen pills.

    However, since most of the estrogen will stay in the vaginal tissue, this type of treatment will not help with hot flashes or osteoporosis. 

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